General Information of the Compound
Compound ID
CP0534067
Compound Name
1-(3-fluorophenyl)sulfonyl-N-[[4-(methylsulfonylmethyl)-2-(trifluoromethyl)phenyl]methyl]indole-5-carboxamide
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Structure
Formula
C25H20F4N2O5S2
Molecular Weight
568.57
Canonical SMILES
CS(=O)(=O)Cc1ccc(CNC(=O)c2ccc3n(ccc3c2)S(=O)(=O)c2cccc(F)c2)c(c1)C(F)(F)F
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InChI
InChI=1S/C25H20F4N2O5S2/c1-37(33,34)15-16-5-6-19(22(11-16)25(27,28)29)14-30-24(32)18-7-8-23-17(12-18)9-10-31(23)38(35,36)21-4-2-3-20(26)13-21/h2-13H,14-15H2,1H3,(H,30,32)
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InChIKey
RJGNSMAVUQZRFP-UHFFFAOYSA-N
Physicochemical Property
logP
4.5108
Rotatable Bonds
7
Heavy Atom Count
38
Polar Areas
102.31
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 166626004
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00915, Peroxisome proliferator-activated receptor gamma
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
EC50 = 660 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 900 nM
2 IC50 = 840 nM