General Information of the Compound
Compound ID
CP0533032
Compound Name
2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-((R)-3-(4-fluorobenzyloxy)pyrrolidine-1-carbonyl)-1H-pyrazol-4-yl)acetonitrile
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Structure
Formula
C29H23Cl2FN4O2
Molecular Weight
549.433
Canonical SMILES
Fc1ccc(CO[C@@H]2CCN(C2)C(=O)c2nn(c(c2CC#N)-c2ccc(Cl)cc2)-c2ccccc2Cl)cc1
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InChI
InChI=1S/C29H23Cl2FN4O2/c30-21-9-7-20(8-10-21)28-24(13-15-33)27(34-36(28)26-4-2-1-3-25(26)31)29(37)35-16-14-23(17-35)38-18-19-5-11-22(32)12-6-19/h1-12,23H,13-14,16-18H2/t23-/m1/s1
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InChIKey
XXSLJISEFOLKBX-HSZRJFAPSA-N
Physicochemical Property
logP
6.48258
Rotatable Bonds
7
Heavy Atom Count
38
Polar Areas
71.15
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46225236
ChEMBL ID
CHEMBL604456
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01298, Cannabinoid receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
IC50 = 20 nM
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