General Information of the Compound
Compound ID
CP0530261
Compound Name
4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-[2-(2,2,2-trifluoroethyl)phenyl]-1,3-thiazol-2-amine
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Structure
Formula
C16H14F3N3S2
Molecular Weight
369.437
Canonical SMILES
Cc1nc(C)c(s1)-c1csc(Nc2ccccc2CC(F)(F)F)n1
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InChI
InChI=1S/C16H14F3N3S2/c1-9-14(24-10(2)20-9)13-8-23-15(22-13)21-12-6-4-3-5-11(12)7-16(17,18)19/h3-6,8H,7H2,1-2H3,(H,21,22)
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InChIKey
KXQMKYSYFLEGEO-UHFFFAOYSA-N
Physicochemical Property
logP
5.73184
Rotatable Bonds
4
Heavy Atom Count
24
Polar Areas
37.81
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155529986
ChEMBL ID
CHEMBL4463839
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
EC50 = 8500 nM
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