General Information of the Compound
Compound ID
CP0527158
Compound Name
1-(6-(4-(3,6-bis(3-(pyrrolidin-1-yl)propanamido)acridin-9-ylamino)phenylamino)-6-oxohexanoyl)piperidine 1-oxide
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Structure
Formula
C44H56N8O5
Molecular Weight
776.983
Canonical SMILES
[O-][N+]1(CCCCC1)C(=O)CCCCC(=O)Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
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InChI
InChI=1S/C44H56N8O5/c53-40(10-2-3-11-43(56)52(57)28-8-1-9-29-52)45-32-12-14-33(15-13-32)48-44-36-18-16-34(46-41(54)20-26-50-22-4-5-23-50)30-38(36)49-39-31-35(17-19-37(39)44)47-42(55)21-27-51-24-6-7-25-51/h12-19,30-31H,1-11,20-29H2,(H,45,53)(H,46,54)(H,47,55)(H,48,49)
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InChIKey
DNLSELMHAILQJI-UHFFFAOYSA-N
Physicochemical Property
logP
7.5044
Rotatable Bonds
16
Heavy Atom Count
57
Polar Areas
158.83
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
9
Complexity
57

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46883445
ChEMBL ID
CHEMBL1078222
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01466, Telomerase reverse transcriptase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000072 A2780 Homo sapiens (Human)  1
1
IC50 = 267 nM
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