General Information of the Compound
Compound ID
CP0526790
Compound Name
1-tert-butyl-3-((5'-chloro-3,3'-difluoro-2'-(2-methyl-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1-hydroxyurea
    Show/Hide
Structure
Formula
C19H20ClF2N7O2
Molecular Weight
451.865
Canonical SMILES
Cn1nnc(n1)-c1c(F)cc(Cl)cc1-c1cnc(CNC(=O)N(O)C(C)(C)C)c(F)c1
    Show/Hide
InChI
InChI=1S/C19H20ClF2N7O2/c1-19(2,3)29(31)18(30)24-9-15-13(21)5-10(8-23-15)12-6-11(20)7-14(22)16(12)17-25-27-28(4)26-17/h5-8,31H,9H2,1-4H3,(H,24,30)
    Show/Hide
InChIKey
YDNCDRQVYZSSRL-UHFFFAOYSA-N
Physicochemical Property
logP
3.57
Rotatable Bonds
4
Heavy Atom Count
31
Polar Areas
109.06
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 46230940
ChEMBL ID
CHEMBL597236
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01032, B1 bradykinin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000411 IMR-90 Homo sapiens (Human)  1
1
IC50 = 1.4 nM
   TI
   LI
   LO
   TS