General Information of the Compound
Compound ID
CP0526789
Compound Name
3-((5'-chloro-3,3'-difluoro-2'-(2-methyl-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1-hydroxy-1-methylurea
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Structure
Formula
C16H14ClF2N7O2
Molecular Weight
409.784
Canonical SMILES
CN(O)C(=O)NCc1ncc(cc1F)-c1cc(Cl)cc(F)c1-c1nnn(C)n1
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InChI
InChI=1S/C16H14ClF2N7O2/c1-25(28)16(27)21-7-13-11(18)3-8(6-20-13)10-4-9(17)5-12(19)14(10)15-22-24-26(2)23-15/h3-6,28H,7H2,1-2H3,(H,21,27)
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InChIKey
ROSKUTAZMURVPJ-UHFFFAOYSA-N
Physicochemical Property
logP
2.4013
Rotatable Bonds
4
Heavy Atom Count
28
Polar Areas
109.06
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46230893
ChEMBL ID
CHEMBL597840
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01032, B1 bradykinin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000411 IMR-90 Homo sapiens (Human)  1
1
IC50 = 17 nM
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