General Information of the Compound
Compound ID
CP0524333
Compound Name
(R)-N-((R)-7-((tert-butylamino)methyl)chroman-4-yl)-3-(3-chloro-2-methylphenylsulfonamido)-3-phenylpropanamide
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Structure
Formula
C30H36ClN3O4S
Molecular Weight
570.155
Canonical SMILES
Cc1c(Cl)cccc1S(=O)(=O)N[C@H](CC(=O)N[C@@H]1CCOc2cc(CNC(C)(C)C)ccc12)c1ccccc1
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InChI
InChI=1S/C30H36ClN3O4S/c1-20-24(31)11-8-12-28(20)39(36,37)34-26(22-9-6-5-7-10-22)18-29(35)33-25-15-16-38-27-17-21(13-14-23(25)27)19-32-30(2,3)4/h5-14,17,25-26,32,34H,15-16,18-19H2,1-4H3,(H,33,35)/t25-,26-/m1/s1
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InChIKey
RFZOXQFIPGWDKX-CLJLJLNGSA-N
Physicochemical Property
logP
5.58622
Rotatable Bonds
9
Heavy Atom Count
39
Polar Areas
96.53
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 16221226
SID: 24903700
ChEMBL ID
CHEMBL390603
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01032, B1 bradykinin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000389 CHO-DXB11 Cricetulus griseus (Chinese hamster)  2
1
IC50 = 207 nM
   TI
   LI
   LO
   TS
2
Ki = 40.6 nM
   TI
   LI
   LO
   TS