General Information of the Compound
Compound ID
CP0524106
Compound Name
N-(5-methyl-1,3-thiazol-2-yl)-2-[(8-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide
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Structure
Formula
C16H14N6OS2
Molecular Weight
370.463
Canonical SMILES
Cc1cnc(NC(=O)CSc2nnc3c(n2)[nH]c2ccc(C)cc32)s1
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InChI
InChI=1S/C16H14N6OS2/c1-8-3-4-11-10(5-8)13-14(18-11)20-16(22-21-13)24-7-12(23)19-15-17-6-9(2)25-15/h3-6H,7H2,1-2H3,(H,17,19,23)(H,18,20,22)
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InChIKey
SQCJGLDOAFXMRT-UHFFFAOYSA-N
Physicochemical Property
logP
3.31024
Rotatable Bonds
4
Heavy Atom Count
25
Polar Areas
96.45
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 6402968
ChEMBL ID
CHEMBL2070724
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
Ki = 3981.07 nM
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