General Information of the Compound
Compound ID
CP0520996
Compound Name
3-[(9R,12S,15S,18S,21S,24S,27R,30S,33S,39S,42S,45R)-33-(4-aminobutyl)-15-(2-amino-2-oxoethyl)-9-[[(2S)-1-amino-1-oxopropan-2-yl]carbamoyl]-45-[[(2S)-2-aminopropanoyl]amino]-21,42-bis[(4-hydroxyphenyl)methyl]-24-methyl-18-(2-methylsulfanylethyl)-4,11,14,17,20,23,26,29,32,35,38,41,44,50,53-pentadecaoxo-12,39-di(propan-2-yl)-7,47,56-trithia-1,3,10,13,16,19,22,25,28,31,34,37,40,43,51-pentadecazatricyclo[25.25.5.13,51]octapentacontan-30-yl]propanoic acid
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Structure
Formula
C80H121N21O23S4
Molecular Weight
1873.24
Canonical SMILES
CSCC[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H]2CSCCC(=O)N3CN(CN(C3)C(=O)CCSC[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)C(=O)CCSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(C)C)C(=O)N[C@@H](C)C(N)=O
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InChI
InChI=1S/C80H121N21O23S4/c1-41(2)65-79(123)85-34-60(105)88-50(11-9-10-26-81)70(114)89-51(20-21-64(109)110)71(115)95-56-35-126-28-23-61(106)99-38-100(40-101(39-99)63(108)25-30-128-37-58(94-68(112)43(5)82)78(122)92-54(74(118)97-65)32-47-14-18-49(103)19-15-47)62(107)24-29-127-36-57(76(120)86-44(6)67(84)111)96-80(124)66(42(3)4)98-75(119)55(33-59(83)104)93-72(116)52(22-27-125-8)90-73(117)53(31-46-12-16-48(102)17-13-46)91-69(113)45(7)87-77(56)121/h12-19,41-45,50-58,65-66,102-103H,9-11,20-40,81-82H2,1-8H3,(H2,83,104)(H2,84,111)(H,85,123)(H,86,120)(H,87,121)(H,88,105)(H,89,114)(H,90,117)(H,91,113)(H,92,122)(H,93,116)(H,94,112)(H,95,115)(H,96,124)(H,97,118)(H,98,119)(H,109,110)/t43-,44-,45-,50-,51-,52-,53-,54-,55-,56-,57-,58-,65-,66-/m0/s1
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InChIKey
XBODMELLTPLXAP-WSPRUDPQSA-N
Physicochemical Property
logP
-6.1228
Rotatable Bonds
23
Heavy Atom Count
128
Polar Areas
684.31
Hydrogen Bond Donor Count
21
Hydrogen Bond Acceptor Count
28
Complexity
128

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 156013992
ChEMBL ID
CHEMBL4635141
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01335, Ephrin type-A receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 210 nM
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   LI
   LO
   TS