General Information of the Compound
Compound ID
CP0517637
Compound Name
[4-[(3-chloro-4-piperidin-4-yloxyphenyl)methyl]piperazin-1-yl]-[5-(4-nitrophenyl)furan-2-yl]methanone
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Structure
Formula
C27H29ClN4O5
Molecular Weight
525.005
Canonical SMILES
[O-][N+](=O)c1ccc(cc1)-c1ccc(o1)C(=O)N1CCN(Cc2ccc(OC3CCNCC3)c(Cl)c2)CC1
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InChI
InChI=1S/C27H29ClN4O5/c28-23-17-19(1-6-25(23)36-22-9-11-29-12-10-22)18-30-13-15-31(16-14-30)27(33)26-8-7-24(37-26)20-2-4-21(5-3-20)32(34)35/h1-8,17,22,29H,9-16,18H2
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InChIKey
CECKQBMLAKWVDC-UHFFFAOYSA-N
Physicochemical Property
logP
4.597
Rotatable Bonds
7
Heavy Atom Count
37
Polar Areas
101.09
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 142747279
ChEMBL ID
CHEMBL4555094
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02463, Urotensin-2 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 31 nM
   TI
   LI
   LO
   TS
CL000866 HEK293 AequoScreen Homo sapiens (Human)  1
1
IC50 = 70 nM
   TI
   LI
   LO
   TS