General Information of the Compound
Compound ID
CP0516897
Compound Name
5-amino-N-[[4-[[(2S)-1-[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]-4-cyclohexyl-1-oxobutan-2-yl]carbamoyl]phenyl]methyl]-1-phenylpyrazole-4-carboxamide
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Formula
C39H44N8O4
Molecular Weight
688.833
Canonical SMILES
Nc1c(cnn1-c1ccccc1)C(=O)NCc1ccc(cc1)C(=O)N[C@@H](CCC1CCCCC1)C(=O)N1CCN(CC1)c1nc2ccccc2o1
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InChI
InChI=1S/C39H44N8O4/c40-35-31(26-42-47(35)30-11-5-2-6-12-30)37(49)41-25-28-15-18-29(19-16-28)36(48)43-33(20-17-27-9-3-1-4-10-27)38(50)45-21-23-46(24-22-45)39-44-32-13-7-8-14-34(32)51-39/h2,5-8,11-16,18-19,26-27,33H,1,3-4,9-10,17,20-25,40H2,(H,41,49)(H,43,48)/t33-/m0/s1
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InChIKey
QKJPGUOUNQFJTH-XIFFEERXSA-N
Physicochemical Property
logP
5.3334
Rotatable Bonds
11
Heavy Atom Count
51
Polar Areas
151.62
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
9
Complexity
51

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4780033
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00861, Mitogen-activated protein kinase 14
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 = 462 nM
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