General Information of the Compound
Compound ID
CP0510458
Compound Name
N-[4-[5-[(E)-(5-oxo-2-sulfanylideneimidazolidin-4-ylidene)methyl]thiophen-2-yl]phenyl]methanesulfonamide
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Structure
Formula
C15H13N3O3S3
Molecular Weight
379.488
Canonical SMILES
CS(=O)(=O)Nc1ccc(cc1)-c1ccc(\C=C2\NC(=S)NC2=O)s1
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InChI
InChI=1S/C15H13N3O3S3/c1-24(20,21)18-10-4-2-9(3-5-10)13-7-6-11(23-13)8-12-14(19)17-15(22)16-12/h2-8,18H,1H3,(H2,16,17,19,22)/b12-8+
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InChIKey
SLYQFCKASSQNQF-XYOKQWHBSA-N
Physicochemical Property
logP
2.1318
Rotatable Bonds
4
Heavy Atom Count
24
Polar Areas
87.3
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53261715
SID: 124403053
ChEMBL ID
CHEMBL3104026
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05158, Perforin-1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat Homo sapiens (Human)  1
1
IC50 = 7700 nM
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