General Information of the Compound
Compound ID
CP0506999
Compound Name
2-[[(E)-4-oxo-4-phenylbut-2-en-2-yl]amino]-3-[4-[2-[4-[(E)-2-phenylethenyl]phenoxy]ethoxy]phenyl]propanoic acid
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Structure
Formula
C35H33NO5
Molecular Weight
547.651
Canonical SMILES
C\C(NC(Cc1ccc(OCCOc2ccc(\C=C\c3ccccc3)cc2)cc1)C(O)=O)=C/C(=O)c1ccccc1
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InChI
InChI=1S/C35H33NO5/c1-26(24-34(37)30-10-6-3-7-11-30)36-33(35(38)39)25-29-16-20-32(21-17-29)41-23-22-40-31-18-14-28(15-19-31)13-12-27-8-4-2-5-9-27/h2-21,24,33,36H,22-23,25H2,1H3,(H,38,39)/b13-12+,26-24+
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InChIKey
LJCBFOPJUDOLHP-HINCYOGESA-N
Physicochemical Property
logP
6.6868
Rotatable Bonds
14
Heavy Atom Count
41
Polar Areas
84.86
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118721127
ChEMBL ID
CHEMBL3355859
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00915, Peroxisome proliferator-activated receptor gamma
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 12 nM
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