General Information of the Compound
Compound ID
CP0505373
Compound Name
(3E)-3-(ethoxyimino)-2-[(4-{2-[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy}phenyl)methyl]butanoic acid
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Structure
Formula
C25H27FN2O5
Molecular Weight
454.498
Canonical SMILES
CCO\N=C(/C)C(Cc1ccc(OCCc2nc(oc2C)-c2ccc(F)cc2)cc1)C(O)=O
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InChI
InChI=1S/C25H27FN2O5/c1-4-32-28-16(2)22(25(29)30)15-18-5-11-21(12-6-18)31-14-13-23-17(3)33-24(27-23)19-7-9-20(26)10-8-19/h5-12,22H,4,13-15H2,1-3H3,(H,29,30)/b28-16+
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InChIKey
BOUVSJWKRSSLFE-LQKURTRISA-N
Physicochemical Property
logP
5.06632
Rotatable Bonds
11
Heavy Atom Count
33
Polar Areas
94.15
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11453821
SID: 16552876
ChEMBL ID
CHEMBL230411
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00910, Peroxisome proliferator-activated receptor alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 11.5 nM
   TI
   LI
   LO
   TS
Protein ID: PT00915, Peroxisome proliferator-activated receptor gamma
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 3 nM
   TI
   LI
   LO
   TS