General Information of the Compound
Compound ID
CP0504391
Compound Name
(R)-3'-methyl-2-((2-oxo-3-(pyridin-2-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)-6,8-dihydrospiro[cyclopenta[g]quinoline-7,4'-imidazolidine]-2',5'-dione
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Structure
Formula
C28H22N6O3
Molecular Weight
490.523
Canonical SMILES
CN1C(=O)NC(=O)[C@]11Cc2cc3ccc(Cn4c5ccccc5n(-c5ccccn5)c4=O)nc3cc2C1
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InChI
InChI=1S/C28H22N6O3/c1-32-26(36)31-25(35)28(32)14-18-12-17-9-10-20(30-21(17)13-19(18)15-28)16-33-22-6-2-3-7-23(22)34(27(33)37)24-8-4-5-11-29-24/h2-13H,14-16H2,1H3,(H,31,35,36)/t28-/m1/s1
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InChIKey
NRHGKVLLFNKYDA-MUUNZHRXSA-N
Physicochemical Property
logP
2.8027
Rotatable Bonds
3
Heavy Atom Count
37
Polar Areas
102.12
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46885132
ChEMBL ID
CHEMBL1091903
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01670, Calcitonin gene-related peptide type 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 17 nM
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