General Information of the Compound
Compound ID
CP0503310
Compound Name
2-(3,4-difluorophenoxy)-N-((1S,3S)-3-(1-(4-(trifluoromethyl)phenyl)-1H-pyrrol-3-ylamino)cyclopentyl)acetamide
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Structure
Formula
C24H22F5N3O2
Molecular Weight
479.449
Canonical SMILES
Fc1ccc(OCC(=O)N[C@H]2CC[C@@H](C2)Nc2ccn(c2)-c2ccc(cc2)C(F)(F)F)cc1F
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InChI
InChI=1S/C24H22F5N3O2/c25-21-8-7-20(12-22(21)26)34-14-23(33)31-17-4-3-16(11-17)30-18-9-10-32(13-18)19-5-1-15(2-6-19)24(27,28)29/h1-2,5-10,12-13,16-17,30H,3-4,11,14H2,(H,31,33)/t16-,17-/m0/s1
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InChIKey
SEKVILZRGOVORW-IRXDYDNUSA-N
Physicochemical Property
logP
5.3025
Rotatable Bonds
7
Heavy Atom Count
34
Polar Areas
55.29
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44562521
ChEMBL ID
CHEMBL488886
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 2260 nM
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