General Information of the Compound
Compound ID
CP0501898
Compound Name
N-[1-[[(1R)-1-[4-(2,5-dimethylpyrrolidine-1-carbonyl)phenyl]ethyl]carbamoyl]cyclopropyl]pyrimidine-5-carboxamide
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Structure
Formula
C24H29N5O3
Molecular Weight
435.528
Canonical SMILES
C[C@@H](NC(=O)C1(CC1)NC(=O)c1cncnc1)c1ccc(cc1)C(=O)N1C(C)CCC1C
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InChI
InChI=1S/C24H29N5O3/c1-15-4-5-16(2)29(15)22(31)19-8-6-18(7-9-19)17(3)27-23(32)24(10-11-24)28-21(30)20-12-25-14-26-13-20/h6-9,12-17H,4-5,10-11H2,1-3H3,(H,27,32)(H,28,30)/t15?,16?,17-/m1/s1
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InChIKey
VZTOQTNAMXNNBP-OFLPRAFFSA-N
Physicochemical Property
logP
2.6294
Rotatable Bonds
6
Heavy Atom Count
32
Polar Areas
104.29
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25207727
SID: 57414782
ChEMBL ID
CHEMBL591354
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01032, B1 bradykinin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000411 IMR-90 Homo sapiens (Human)  1
1
IC50 = 125 nM
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