General Information of the Compound
Compound ID
CP0498977
Compound Name
2-{9-methyl-2,10-dioxo-1,3,9-triazatricyclo[6.5.1.0^{4,14}]tetradeca-4(14),5,7-trien-3-yl}-N-[(4R)-3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-6'-yl]acetamide
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Structure
Formula
C26H26N6O5
Molecular Weight
502.531
Canonical SMILES
CN1C(=O)NC(=O)[C@]11Cc2ccc(NC(=O)Cn3c4cccc5N(C)C(=O)CCCn(c45)c3=O)cc2C1
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InChI
InChI=1S/C26H26N6O5/c1-29-18-5-3-6-19-22(18)31(10-4-7-21(29)34)25(37)32(19)14-20(33)27-17-9-8-15-12-26(13-16(15)11-17)23(35)28-24(36)30(26)2/h3,5-6,8-9,11H,4,7,10,12-14H2,1-2H3,(H,27,33)(H,28,35,36)/t26-/m1/s1
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InChIKey
YHBAXXSGIRBQNO-AREMUKBSSA-N
Physicochemical Property
logP
1.2173
Rotatable Bonds
3
Heavy Atom Count
37
Polar Areas
125.75
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44563200
ChEMBL ID
CHEMBL455458
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01670, Calcitonin gene-related peptide type 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  3
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
2
IC50 = 13 nM
   TI
   LI
   LO
   TS
3
Ki = 2.2 nM
   TI
   LI
   LO
   TS