General Information of the Compound
Compound ID
CP0498317
Compound Name
(4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[2-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-(benzylamino)-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1,4-dioxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[2-[[(2S)-2-[[(2S)-1-[2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-oxopentanoic acid
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Structure
Formula
C134H201N37O37
Molecular Weight
2922.304
Canonical SMILES
CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccccc1
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InChI
InChI=1S/C134H201N37O37/c1-72(2)54-89(167-131(207)101-40-27-53-171(101)108(183)68-151-117(193)98(69-172)170-132(208)111(139)76(8)175)114(190)149-67-107(182)155-97(62-103(138)178)128(204)163-90(55-73(3)4)123(199)152-75(7)112(188)156-87(45-47-109(184)185)121(197)161-88(46-48-110(186)187)122(198)162-91(56-74(5)6)124(200)166-96(61-102(137)177)116(192)150-66-106(181)154-94(60-80-41-43-82(176)44-42-80)126(202)168-99(70-173)129(205)160-85(38-25-51-144-133(140)141)119(195)158-84(37-22-24-50-136)118(194)157-83(36-21-23-49-135)113(189)148-64-104(179)146-65-105(180)153-93(58-78-30-15-10-16-31-78)125(201)169-100(71-174)130(206)165-95(59-79-32-17-11-18-33-79)127(203)159-86(39-26-52-145-134(142)143)120(196)164-92(57-77-28-13-9-14-29-77)115(191)147-63-81-34-19-12-20-35-81/h9-20,28-35,41-44,72-76,83-101,111,172-176H,21-27,36-40,45-71,135-136,139H2,1-8H3,(H2,137,177)(H2,138,178)(H,146,179)(H,147,191)(H,148,189)(H,149,190)(H,150,192)(H,151,193)(H,152,199)(H,153,180)(H,154,181)(H,155,182)(H,156,188)(H,157,194)(H,158,195)(H,159,203)(H,160,205)(H,161,197)(H,162,198)(H,163,204)(H,164,196)(H,165,206)(H,166,200)(H,167,207)(H,168,202)(H,169,201)(H,170,208)(H,184,185)(H,186,187)(H4,140,141,144)(H4,142,143,145)/t75-,76+,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,111-/m0/s1
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InChIKey
GMOYPWQVVRLIHP-CENRIGGDSA-N
Physicochemical Property
logP
-13.5488
Rotatable Bonds
96
Heavy Atom Count
208
Polar Areas
1216.6
Hydrogen Bond Donor Count
41
Hydrogen Bond Acceptor Count
40
Complexity
208

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53363631
SID: 125266563
ChEMBL ID
CHEMBL1802480
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05331, Pyroglutamylated RF-amide peptide receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
EC50 = 39 nM
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