General Information of the Compound
Compound ID
CP0497221
Compound Name
4-[(N-Cyclohexyl-4-pyrimidin-2-yl-piperazine-1-carboximidoyl)-amino]-N-[2-(2,4-dichloro-phenyl)-ethyl]-benzamide
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Structure
Formula
C30H35Cl2N7O
Molecular Weight
580.564
Canonical SMILES
Clc1ccc(CCNC(=O)c2ccc(NC(=NC3CCCCC3)N3CCN(CC3)c3ncccn3)cc2)c(Cl)c1
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InChI
InChI=1S/C30H35Cl2N7O/c31-24-10-7-22(27(32)21-24)13-16-33-28(40)23-8-11-26(12-9-23)37-30(36-25-5-2-1-3-6-25)39-19-17-38(18-20-39)29-34-14-4-15-35-29/h4,7-12,14-15,21,25H,1-3,5-6,13,16-20H2,(H,33,40)(H,36,37)
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InChIKey
DLSWARUAQKVVQG-UHFFFAOYSA-N
Physicochemical Property
logP
5.6787
Rotatable Bonds
7
Heavy Atom Count
40
Polar Areas
85.75
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11410616
SID: 16506301
ChEMBL ID
CHEMBL182844
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01804, Melanocortin receptor 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 305 nM
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