General Information of the Compound
Compound ID
CP0496987
Compound Name
3-[2-(2-hydroxyethyl)piperidin-1-yl]-N-[6-[3-[2-(2-hydroxyethyl)piperidin-1-yl]propanoylamino]-9-oxo-10H-acridin-2-yl]propanamide
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Structure
Formula
C33H45N5O5
Molecular Weight
591.753
Canonical SMILES
OCCC1CCCCN1CCC(=O)Nc1ccc2c(O)c3cc(NC(=O)CCN4CCCCC4CCO)ccc3nc2c1
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InChI
InChI=1S/C33H45N5O5/c39-19-13-25-5-1-3-15-37(25)17-11-31(41)34-23-8-10-29-28(21-23)33(43)27-9-7-24(22-30(27)36-29)35-32(42)12-18-38-16-4-2-6-26(38)14-20-40/h7-10,21-22,25-26,39-40H,1-6,11-20H2,(H,34,41)(H,35,42)(H,36,43)
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InChIKey
JCDJTQVXTSHHLI-UHFFFAOYSA-N
Physicochemical Property
logP
4.2246
Rotatable Bonds
12
Heavy Atom Count
43
Polar Areas
138.26
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
8
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 91937022
ChEMBL ID
CHEMBL3707105
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01466, Telomerase reverse transcriptase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000072 A2780 Homo sapiens (Human)  1
1
IC50 = 200 nM
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