General Information of the Compound
Compound ID
CP0493920
Compound Name
N-(3-morpholin-4-ylpropyl)-4-[5-[(E)-(5-oxo-2-sulfanylideneimidazolidin-4-ylidene)methyl]thiophen-2-yl]benzamide
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Structure
Formula
C22H24N4O3S2
Molecular Weight
456.593
Canonical SMILES
O=C(NCCCN1CCOCC1)c1ccc(cc1)-c1ccc(\C=C2\NC(=S)NC2=O)s1
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InChI
InChI=1S/C22H24N4O3S2/c27-20(23-8-1-9-26-10-12-29-13-11-26)16-4-2-15(3-5-16)19-7-6-17(31-19)14-18-21(28)25-22(30)24-18/h2-7,14H,1,8-13H2,(H,23,27)(H2,24,25,28,30)/b18-14+
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InChIKey
JXFUPWPWSXMEHQ-NBVRZTHBSA-N
Physicochemical Property
logP
2.2124
Rotatable Bonds
7
Heavy Atom Count
31
Polar Areas
82.7
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
6
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53261833
SID: 124403170
ChEMBL ID
CHEMBL3103901
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05158, Perforin-1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat Homo sapiens (Human)  1
1
IC50 = 8130 nM
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