General Information of the Compound
Compound ID
CP0490852
Compound Name
4-{2-[(adamantane-1-carbonyl)-amino]-5,7,7,10,10-pentamethyl-7,8,9,10-tetrahydro-5H-5,13-diaza-benzo[4,5]cyclohepta[1,2-b]naphthalen-12-yl}-benzoic acid
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Structure
Formula
C40H45N3O3
Molecular Weight
615.818
Canonical SMILES
CN1c2ccc(NC(=O)C34CC5CC(CC(C5)C3)C4)cc2N=C(c2ccc(cc2)C(O)=O)c2cc3c(cc12)C(C)(C)CCC3(C)C
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InChI
InChI=1S/C40H45N3O3/c1-38(2)12-13-39(3,4)31-19-34-29(18-30(31)38)35(26-6-8-27(9-7-26)36(44)45)42-32-17-28(10-11-33(32)43(34)5)41-37(46)40-20-23-14-24(21-40)16-25(15-23)22-40/h6-11,17-19,23-25H,12-16,20-22H2,1-5H3,(H,41,46)(H,44,45)
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InChIKey
NZZKAWXHZHZEFK-UHFFFAOYSA-N
Physicochemical Property
logP
9.1391
Rotatable Bonds
4
Heavy Atom Count
46
Polar Areas
82
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
46

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44433377
ChEMBL ID
CHEMBL394721
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01930, Retinoic acid receptor RXR-alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 2900 nM
   TI
   LI
   LO
   TS
2
IC50 = 7200 nM
   TI
   LI
   LO
   TS