General Information of the Compound
Compound ID
CP0488592
Compound Name
US9464076, 125
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Structure
Formula
C29H32N4O3S
Molecular Weight
516.667
Canonical SMILES
COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCN(C)CC4)c4ccccc4n3)c(C)c12
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InChI
InChI=1S/C29H32N4O3S/c1-18-26-20(17-36-4)9-10-22(19(2)34)28(26)37-27(18)29(35)31-25-15-21(16-33-13-11-32(3)12-14-33)23-7-5-6-8-24(23)30-25/h5-10,15H,11-14,16-17H2,1-4H3,(H,30,31,35)
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InChIKey
CNTHIKFUQVZPFN-UHFFFAOYSA-N
Physicochemical Property
logP
5.10662
Rotatable Bonds
7
Heavy Atom Count
37
Polar Areas
74.77
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118658321
ChEMBL ID
CHEMBL3937047
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01875, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat Homo sapiens (Human)  1
1
IC50 = 0.8 nM
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