General Information of the Compound
Compound ID
CP0486781
Compound Name
2-[3-(4-methylpiperazin-1-yl)propyl]-5-[5-[(E)-(5-oxo-2-sulfanylideneimidazolidin-4-ylidene)methyl]thiophen-2-yl]-3H-isoindol-1-one
    Show/Hide
Structure
Formula
C24H27N5O2S2
Molecular Weight
481.647
Canonical SMILES
CN1CCN(CCCN2Cc3cc(ccc3C2=O)-c2ccc(\C=C3\NC(=S)NC3=O)s2)CC1
    Show/Hide
InChI
InChI=1S/C24H27N5O2S2/c1-27-9-11-28(12-10-27)7-2-8-29-15-17-13-16(3-5-19(17)23(29)31)21-6-4-18(33-21)14-20-22(30)26-24(32)25-20/h3-6,13-14H,2,7-12,15H2,1H3,(H2,25,26,30,32)/b20-14+
    Show/Hide
InChIKey
ZDAYCZZUPJPGIU-XSFVSMFZSA-N
Physicochemical Property
logP
2.3536
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
67.92
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 53262096
SID: 124403434
ChEMBL ID
CHEMBL3104005
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05158, Perforin-1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat Homo sapiens (Human)  1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS