General Information of the Compound
Compound ID
CP0486406
Compound Name
3-Amino-N-((R)-1-(2,4-dichloro-benzyl)-2-oxo-2-{4-[1-(phenylacetylamino-methyl)-cyclohexyl]-piperazin-1-yl}-ethyl)-propionamide
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Structure
Formula
C31H41Cl2N5O3
Molecular Weight
602.607
Canonical SMILES
NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)C1(CNC(=O)Cc2ccccc2)CCCCC1
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InChI
InChI=1S/C31H41Cl2N5O3/c32-25-10-9-24(26(33)21-25)20-27(36-28(39)11-14-34)30(41)37-15-17-38(18-16-37)31(12-5-2-6-13-31)22-35-29(40)19-23-7-3-1-4-8-23/h1,3-4,7-10,21,27H,2,5-6,11-20,22,34H2,(H,35,40)(H,36,39)/t27-/m1/s1
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InChIKey
HHHGGOMKUAYOJZ-HHHXNRCGSA-N
Physicochemical Property
logP
3.5755
Rotatable Bonds
11
Heavy Atom Count
41
Polar Areas
107.77
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44397198
ChEMBL ID
CHEMBL185862
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01325, Melanocortin receptor 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 710 nM
   TI
   LI
   LO
   TS
Protein ID: PT00914, Melanocortin receptor 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
Ki = 6.4 nM
   TI
   LI
   LO
   TS
2
Ki = 8.8 nM
   TI
   LI
   LO
   TS
Protein ID: PT01804, Melanocortin receptor 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 920 nM
   TI
   LI
   LO
   TS