General Information of the Compound
Compound ID
CP0486302
Compound Name
US9346786, 81
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Structure
Formula
C26H30ClF2N3O5S
Molecular Weight
570.058
Canonical SMILES
CCN([C@@H]1CN(C[C@H]1c1ccc(Cl)c(F)c1)C(=O)C1CCN(CC1)S(C)(=O)=O)C(=O)Oc1ccc(F)cc1
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InChI
InChI=1S/C26H30ClF2N3O5S/c1-3-32(26(34)37-20-7-5-19(28)6-8-20)24-16-30(15-21(24)18-4-9-22(27)23(29)14-18)25(33)17-10-12-31(13-11-17)38(2,35)36/h4-9,14,17,21,24H,3,10-13,15-16H2,1-2H3/t21-,24+/m0/s1
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InChIKey
WYAWFWHOVHCJQS-XUZZJYLKSA-N
Physicochemical Property
logP
4.1051
Rotatable Bonds
6
Heavy Atom Count
38
Polar Areas
87.23
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53247484
SID: 124363815
ChEMBL ID
CHEMBL3980824
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01199, Neuromedin-K receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 29 nM
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   LI
   LO
   TS