General Information of the Compound
Compound ID
CP0485980
Compound Name
N-[2-[[4-[5-chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2-fluorophenyl]methylamino]-4,5-dimethylimidazol-1-yl]acetamide
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Structure
Formula
C23H21ClF2N6O2
Molecular Weight
486.91
Canonical SMILES
CC(=O)Nn1c(C)c(C)nc1NCc1ccc(cc1F)-c1cc(Cl)cc(F)c1-c1noc(C)n1
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InChI
InChI=1S/C23H21ClF2N6O2/c1-11-12(2)32(30-13(3)33)23(28-11)27-10-16-6-5-15(7-19(16)25)18-8-17(24)9-20(26)21(18)22-29-14(4)34-31-22/h5-9H,10H2,1-4H3,(H,27,28)(H,30,33)
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InChIKey
FEOLETOGADNCJT-UHFFFAOYSA-N
Physicochemical Property
logP
5.15906
Rotatable Bonds
6
Heavy Atom Count
34
Polar Areas
97.87
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46230258
ChEMBL ID
CHEMBL598348
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01032, B1 bradykinin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000411 IMR-90 Homo sapiens (Human)  1
1
IC50 = 180 nM
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