General Information of the Compound
Compound ID
CP0485784
Compound Name
3-(4-benzylphenyl)-8-fluoro-2-(4-methylpiperazin-1-yl)quinazolin-4-one
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Structure
Formula
C26H25FN4O
Molecular Weight
428.511
Canonical SMILES
CN1CCN(CC1)c1nc2c(F)cccc2c(=O)n1-c1ccc(Cc2ccccc2)cc1
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InChI
InChI=1S/C26H25FN4O/c1-29-14-16-30(17-15-29)26-28-24-22(8-5-9-23(24)27)25(32)31(26)21-12-10-20(11-13-21)18-19-6-3-2-4-7-19/h2-13H,14-18H2,1H3
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InChIKey
HZAQSUDKHPXQSV-UHFFFAOYSA-N
Physicochemical Property
logP
3.8674
Rotatable Bonds
4
Heavy Atom Count
32
Polar Areas
41.37
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155551656
ChEMBL ID
CHEMBL4542977
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03081, Transient receptor potential cation channel subfamily V member 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 670 nM
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