General Information of the Compound
Compound ID
CP0485744
Compound Name
1-((1-(2-(4-chlorobenzyloxy)-5-bromobenzyl)-4-hydroxypiperidin-4-yl)methyl)-3-(2,4,6-trichlorophenyl)urea
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Structure
Formula
C27H26BrCl4N3O3
Molecular Weight
662.239
Canonical SMILES
OC1(CNC(=O)Nc2c(Cl)cc(Cl)cc2Cl)CCN(Cc2cc(Br)ccc2OCc2ccc(Cl)cc2)CC1
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InChI
InChI=1S/C27H26BrCl4N3O3/c28-19-3-6-24(38-15-17-1-4-20(29)5-2-17)18(11-19)14-35-9-7-27(37,8-10-35)16-33-26(36)34-25-22(31)12-21(30)13-23(25)32/h1-6,11-13,37H,7-10,14-16H2,(H2,33,34,36)
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InChIKey
VKWCQDVRWAFFKO-UHFFFAOYSA-N
Physicochemical Property
logP
7.7903
Rotatable Bonds
8
Heavy Atom Count
38
Polar Areas
73.83
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
4
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44431975
ChEMBL ID
CHEMBL234017
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 450 nM
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