General Information of the Compound
Compound ID
CP0484693
Compound Name
[4-[(3-chloro-4-piperidin-4-yloxyphenyl)methyl]piperazin-1-yl]-(5-phenylfuran-2-yl)methanone
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Structure
Formula
C27H30ClN3O3
Molecular Weight
480.008
Canonical SMILES
Clc1cc(CN2CCN(CC2)C(=O)c2ccc(o2)-c2ccccc2)ccc1OC1CCNCC1
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InChI
InChI=1S/C27H30ClN3O3/c28-23-18-20(6-7-25(23)33-22-10-12-29-13-11-22)19-30-14-16-31(17-15-30)27(32)26-9-8-24(34-26)21-4-2-1-3-5-21/h1-9,18,22,29H,10-17,19H2
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InChIKey
KNGKMDYIAHOGSZ-UHFFFAOYSA-N
Physicochemical Property
logP
4.6888
Rotatable Bonds
6
Heavy Atom Count
34
Polar Areas
57.95
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 142747289
ChEMBL ID
CHEMBL4450638
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02463, Urotensin-2 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 48 nM
   TI
   LI
   LO
   TS
CL000866 HEK293 AequoScreen Homo sapiens (Human)  1
1
IC50 = 230 nM
   TI
   LI
   LO
   TS