General Information of the Compound
Compound ID
CP0483274
Compound Name
US8933079, 7.2
    Show/Hide
Structure
Formula
C26H30ClN5O3
Molecular Weight
496.011
Canonical SMILES
CCN1CCN(Cc2ccc(C(=O)Cn3ncc(OCc4ccc(Cl)cn4)cc3=O)c(C)c2)CC1
    Show/Hide
InChI
InChI=1S/C26H30ClN5O3/c1-3-30-8-10-31(11-9-30)16-20-4-7-24(19(2)12-20)25(33)17-32-26(34)13-23(15-29-32)35-18-22-6-5-21(27)14-28-22/h4-7,12-15H,3,8-11,16-18H2,1-2H3
    Show/Hide
InChIKey
DOFRFJXSHHPUBE-UHFFFAOYSA-N
Physicochemical Property
logP
3.19952
Rotatable Bonds
9
Heavy Atom Count
35
Polar Areas
80.56
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 91759576
ChEMBL ID
CHEMBL3686834
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000076 CHO/Galpha16 Cricetulus griseus (Chinese hamster)  1
1
IC50 = 71 nM
   TI
   LI
   LO
   TS