General Information of the Compound
Compound ID
CP0480011
Compound Name
1'-benzylspiro[3H-chromene-2,4'-piperidine]-4-one
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Structure
Formula
C20H21NO2
Molecular Weight
307.393
Canonical SMILES
O=C1CC2(CCN(Cc3ccccc3)CC2)Oc2ccccc12
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InChI
InChI=1S/C20H21NO2/c22-18-14-20(23-19-9-5-4-8-17(18)19)10-12-21(13-11-20)15-16-6-2-1-3-7-16/h1-9H,10-15H2
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InChIKey
VYTXCPHULMDKCP-UHFFFAOYSA-N
Physicochemical Property
logP
3.6866
Rotatable Bonds
2
Heavy Atom Count
23
Polar Areas
29.54
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 2427316
SID: 96101410
ChEMBL ID
CHEMBL571659
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01509, Sigma non-opioid intracellular receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat Homo sapiens (Human)  1
1
Ki = 0.2089 nM
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   LI
   LO
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