General Information of the Compound
Compound ID
CP0477932
Compound Name
(2S)-2-[[(3R,6S,9S,12S,15R,20R,23S,26S,29S,32S)-3,6-bis(4-aminobutyl)-15-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-9,23,26-tris(3-carbamimidamidopropyl)-12,29-bis[(4-hydroxyphenyl)methyl]-2,5,8,11,14,22,25,28,31-nonaoxo-17,18-dithia-1,4,7,10,13,21,24,27,30-nonazabicyclo[30.3.0]pentatriacontane-20-carbonyl]amino]-6-[[(2S)-2-[[(2S)-2-[[(2S)-5-carbamimidamido-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]pentanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]hexanoic acid
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Structure
Formula
C136H216N46O31S2
Molecular Weight
3055.649
Canonical SMILES
CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1)C(O)=O
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InChI
InChI=1S/C136H216N46O31S2/c1-73(2)106(180-126(208)105-36-21-61-181(105)128(210)86(141)25-7-11-51-137)127(209)177-100(69-184)121(203)162-75(4)108(190)175-101(70-185)122(204)172-95(64-76-38-45-82(186)46-39-76)116(198)168-91(33-19-59-159-135(150)151)114(196)176-99(68-183)120(202)161-74(3)107(189)154-54-14-10-29-94(130(212)213)170-123(205)102-71-214-215-72-103(179-119(201)98(67-79-37-44-80-23-5-6-24-81(80)63-79)171-113(195)88(30-16-56-156-132(144)145)163-109(191)85(140)26-15-55-155-131(142)143)124(206)173-96(65-77-40-47-83(187)48-41-77)117(199)166-89(31-17-57-157-133(146)147)110(192)164-87(27-8-12-52-138)112(194)169-93(28-9-13-53-139)129(211)182-62-22-35-104(182)125(207)174-97(66-78-42-49-84(188)50-43-78)118(200)167-90(32-18-58-158-134(148)149)111(193)165-92(115(197)178-102)34-20-60-160-136(152)153/h5-6,23-24,37-50,63,73-75,85-106,183-188H,7-22,25-36,51-62,64-72,137-141H2,1-4H3,(H,154,189)(H,161,202)(H,162,203)(H,163,191)(H,164,192)(H,165,193)(H,166,199)(H,167,200)(H,168,198)(H,169,194)(H,170,205)(H,171,195)(H,172,204)(H,173,206)(H,174,207)(H,175,190)(H,176,196)(H,177,209)(H,178,197)(H,179,201)(H,180,208)(H,212,213)(H4,142,143,155)(H4,144,145,156)(H4,146,147,157)(H4,148,149,158)(H4,150,151,159)(H4,152,153,160)/t74-,75-,85-,86-,87-,88-,89-,90-,91-,92-,93+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-/m0/s1
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InChIKey
YECPRBJCADXBPY-MGKIFFHSSA-N
Physicochemical Property
logP
-12.03478
Rotatable Bonds
80
Heavy Atom Count
215
Polar Areas
1311.9
Hydrogen Bond Donor Count
51
Hydrogen Bond Acceptor Count
43
Complexity
215

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 134138899
ChEMBL ID
CHEMBL3933112
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02059, C-X-C chemokine receptor type 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 171 nM
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