General Information of the Compound
Compound ID
CP0477284
Compound Name
2-[(4aS,8aR)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,8,8a-tetrahydrophthalazin-2-yl]-N-(3-imidazol-1-ylpropyl)acetamide
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Structure
Formula
C24H29N5O4
Molecular Weight
451.527
Canonical SMILES
COc1ccc(cc1OC)C1=NN(CC(=O)NCCCn2ccnc2)C(=O)[C@@H]2CC=CC[C@H]12
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InChI
InChI=1S/C24H29N5O4/c1-32-20-9-8-17(14-21(20)33-2)23-18-6-3-4-7-19(18)24(31)29(27-23)15-22(30)26-10-5-12-28-13-11-25-16-28/h3-4,8-9,11,13-14,16,18-19H,5-7,10,12,15H2,1-2H3,(H,26,30)/t18-,19+/m0/s1
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InChIKey
RRNXURXVGGKEOL-RBUKOAKNSA-N
Physicochemical Property
logP
2.2355
Rotatable Bonds
9
Heavy Atom Count
33
Polar Areas
98.05
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46227285
ChEMBL ID
CHEMBL605935
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01538, 3',5'-cyclic-AMP phosphodiesterase 4D
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000018 HL-60 Homo sapiens (Human)  1
1
IC50 = 14.3 nM
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