General Information of the Compound
Compound ID
CP0476509
Compound Name
1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-chlorophenyl)piperazine
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Structure
Formula
C25H25ClF2N2O
Molecular Weight
442.937
Canonical SMILES
Fc1ccc(cc1)C(OCCN1CCN(CC1)c1cccc(Cl)c1)c1ccc(F)cc1
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InChI
InChI=1S/C25H25ClF2N2O/c26-21-2-1-3-24(18-21)30-14-12-29(13-15-30)16-17-31-25(19-4-8-22(27)9-5-19)20-6-10-23(28)11-7-20/h1-11,18,25H,12-17H2
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InChIKey
SZHGPSPMOLWMTN-UHFFFAOYSA-N
Physicochemical Property
logP
5.5464
Rotatable Bonds
7
Heavy Atom Count
31
Polar Areas
15.71
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137643839
ChEMBL ID
CHEMBL4086279
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00884, Sodium-dependent dopamine transporter
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 2749 nM
   TI
   LI
   LO
   TS
Protein ID: PT01026, Sodium-dependent noradrenaline transporter
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 1313 nM
   TI
   LI
   LO
   TS
Protein ID: PT00871, Sodium-dependent serotonin transporter
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 4960 nM
   TI
   LI
   LO
   TS