General Information of the Compound
Compound ID
CP0476270
Compound Name
N-[2-[2-[2-[3-[[12-chloro-2-(1-methyl-2-oxo-4-sulfanylidenepyrimidin-5-yl)-6-thia-4-azatricyclo[8.4.0.03,7]tetradeca-1(10),3(7),4,8,11,13-hexaen-5-yl]amino]propanoylamino]ethoxy]ethoxy]ethyl]-6-[3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)propanoylamino]hexanamide
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Structure
Formula
C46H55BClF2N9O6S2
Molecular Weight
978.398
Canonical SMILES
Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCCCC(=O)NCCOCCOCCNC(=O)CCNc3nc4C(c5ccc(Cl)cc5C=Cc4s3)c3cn(C)c(=O)[nH]c3=S)=[N+]1[B-]2(F)F
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InChI
InChI=1S/C46H55BClF2N9O6S2/c1-29-25-30(2)58-37(29)27-34-11-10-33(59(34)47(58,49)50)12-15-40(61)51-17-6-4-5-7-39(60)52-19-21-64-23-24-65-22-20-53-41(62)16-18-54-45-55-43-38(67-45)14-8-31-26-32(48)9-13-35(31)42(43)36-28-57(3)46(63)56-44(36)66/h8-11,13-14,25-28,42H,4-7,12,15-24H2,1-3H3,(H,51,61)(H,52,60)(H,53,62)(H,54,55)(H,56,63,66)
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InChIKey
MQPNZSPJDOSGMI-UHFFFAOYSA-N
Physicochemical Property
logP
6.46023
Rotatable Bonds
23
Heavy Atom Count
67
Polar Areas
176.41
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
12
Complexity
67

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145961793
ChEMBL ID
CHEMBL4129129
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04714, P2Y purinoceptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000094 1321N1 Homo sapiens (Human)  1
1
Kd = 4168.69 nM
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