General Information of the Compound
Compound ID
CP0476166
Compound Name
6-methyl-2-[4-[4-[1-[2-(4-oxo-2-phenylchromen-7-yl)oxyethyl]triazol-4-yl]butoxy]phenyl]chromen-4-one
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Structure
Formula
C39H33N3O6
Molecular Weight
639.708
Canonical SMILES
Cc1ccc2oc(cc(=O)c2c1)-c1ccc(OCCCCc2cn(CCOc3ccc4c(c3)oc(cc4=O)-c3ccccc3)nn2)cc1
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InChI
InChI=1S/C39H33N3O6/c1-26-10-17-36-33(21-26)35(44)24-38(47-36)28-11-13-30(14-12-28)45-19-6-5-9-29-25-42(41-40-29)18-20-46-31-15-16-32-34(43)23-37(48-39(32)22-31)27-7-3-2-4-8-27/h2-4,7-8,10-17,21-25H,5-6,9,18-20H2,1H3
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InChIKey
WTNMZYHEWMPTBP-UHFFFAOYSA-N
Physicochemical Property
logP
7.61402
Rotatable Bonds
12
Heavy Atom Count
48
Polar Areas
109.59
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
9
Complexity
48

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155555932
ChEMBL ID
CHEMBL4554299
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01546, ATP-dependent translocase ABCB1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000350 MDA435/LCC6MDR1 Homo sapiens (Human)  1
1
EC50 = 204 nM
   TI
   LI
   LO
   TS
Protein ID: PT02718, Broad substrate specificity ATP-binding cassette transporter ABCG2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000462 HEKR2 Homo sapiens (Human)  1
1
EC50 = 60 nM
   TI
   LI
   LO
   TS
CL000415 MCF-7 MX100 Homo sapiens (Human)  1
1
EC50 = 223.3 nM
   TI
   LI
   LO
   TS