General Information of the Compound
Compound ID
CP0473876
Compound Name
N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(6-oxo-3-phenyl-1H-pyridazin-5-yl)piperidine-1-carboxamide
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Structure
Formula
C30H30F5N5O3
Molecular Weight
603.592
Canonical SMILES
Fc1cccc([C@@H]2CC[C@@H](NC(=O)N3CCC(CC3)c3cc(n[nH]c3=O)-c3ccccc3)C(=O)N(CC(F)(F)F)C2)c1F
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InChI
InChI=1S/C30H30F5N5O3/c31-23-8-4-7-21(26(23)32)20-9-10-24(28(42)40(16-20)17-30(33,34)35)36-29(43)39-13-11-18(12-14-39)22-15-25(37-38-27(22)41)19-5-2-1-3-6-19/h1-8,15,18,20,24H,9-14,16-17H2,(H,36,43)(H,38,41)/t20-,24-/m1/s1
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InChIKey
RPBNPWUNODXFRC-HYBUGGRVSA-N
Physicochemical Property
logP
4.9412
Rotatable Bonds
5
Heavy Atom Count
43
Polar Areas
98.4
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45487037
ChEMBL ID
CHEMBL570626
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01670, Calcitonin gene-related peptide type 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 240 nM
   TI
   LI
   LO
   TS