General Information of the Compound
Compound ID
CP0470510
Compound Name
4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-(4-methoxy-2-methylphenyl)-1,3-thiazol-2-amine
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Structure
Formula
C16H17N3OS2
Molecular Weight
331.466
Canonical SMILES
COc1ccc(Nc2nc(cs2)-c2sc(C)nc2C)c(C)c1
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InChI
InChI=1S/C16H17N3OS2/c1-9-7-12(20-4)5-6-13(9)18-16-19-14(8-21-16)15-10(2)17-11(3)22-15/h5-8H,1-4H3,(H,18,19)
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InChIKey
DEGRSYGPQYKWTD-UHFFFAOYSA-N
Physicochemical Property
logP
4.94406
Rotatable Bonds
4
Heavy Atom Count
22
Polar Areas
47.04
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
22

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 126619369
ChEMBL ID
CHEMBL4454409
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
EC50 = 14000 nM
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