General Information of the Compound
Compound ID
CP0468303
Compound Name
(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-acetamido-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-carboxybutanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-carboxybutanoyl]amino]hexanoylamino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]amino]-5-[[(2S)-5-amino-1-[[1-[[(2S)-1-[[(2S)-5-amino-1-[[(3S,6S,9S,18S)-18-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[1-[[(2S)-1-[[1-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-2-methyl-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]carbamoyl]-3-(1H-imidazol-5-ylmethyl)-6-methyl-2,5,8,12-tetraoxo-1,4,7,13-tetrazacyclooctadec-9-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-methyl-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-oxopentanoic acid
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Structure
Formula
C173H286N52O49
Molecular Weight
3878.506
Canonical SMILES
CCCCC(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(C)(C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O
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InChI
InChI=1S/C173H286N52O49/c1-27-30-44-100(201-151(257)110(55-62-129(234)235)209-155(261)117(73-87(10)11)219-165(271)133(89(14)15)221-152(258)111(56-63-130(236)237)208-146(252)106(50-41-69-190-171(183)184)205-154(260)115(71-85(6)7)214-156(262)116(72-86(8)9)215-159(265)121(77-99-81-186-83-192-99)217-157(263)119(75-97-42-33-32-34-43-97)220-166(272)135(95(21)226)222-162(268)118(74-88(12)13)216-161(267)123(79-132(240)241)197-96(22)227)141(247)193-91(17)137(243)198-104(48-39-67-188-169(179)180)142(248)194-92(18)138(244)200-109(54-61-128(232)233)150(256)210-112(52-59-125(176)229)163(269)224-172(23,24)167(273)196-94(20)140(246)199-107(51-58-124(175)228)149(255)207-108-53-60-127(231)187-66-38-36-47-103(204-158(264)120(76-98-80-185-82-191-98)212-139(245)93(19)195-143(108)249)148(254)218-122(78-126(177)230)160(266)206-105(49-40-68-189-170(181)182)145(251)202-102(46-35-37-65-174)147(253)213-114(70-84(4)5)153(259)203-101(45-31-28-2)144(250)211-113(57-64-131(238)239)164(270)225-173(25,26)168(274)223-134(136(178)242)90(16)29-3/h32-34,42-43,80-95,100-123,133-135,226H,27-31,35-41,44-79,174H2,1-26H3,(H2,175,228)(H2,176,229)(H2,177,230)(H2,178,242)(H,185,191)(H,186,192)(H,187,231)(H,193,247)(H,194,248)(H,195,249)(H,196,273)(H,197,227)(H,198,243)(H,199,246)(H,200,244)(H,201,257)(H,202,251)(H,203,259)(H,204,264)(H,205,260)(H,206,266)(H,207,255)(H,208,252)(H,209,261)(H,210,256)(H,211,250)(H,212,245)(H,213,253)(H,214,262)(H,215,265)(H,216,267)(H,217,263)(H,218,254)(H,219,271)(H,220,272)(H,221,258)(H,222,268)(H,223,274)(H,224,269)(H,225,270)(H,232,233)(H,234,235)(H,236,237)(H,238,239)(H,240,241)(H4,179,180,188)(H4,181,182,189)(H4,183,184,190)/t90-,91-,92-,93-,94-,95+,100?,101?,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119+,120-,121-,122-,123-,133-,134-,135-/m0/s1
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InChIKey
UHBZHAJMSZGBHJ-ZFDJBGCZSA-N
Physicochemical Property
logP
-12.40289
Rotatable Bonds
124
Heavy Atom Count
274
Polar Areas
1637.57
Hydrogen Bond Donor Count
56
Hydrogen Bond Acceptor Count
50
Complexity
274

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127031736
ChEMBL ID
CHEMBL3775678
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01588, Corticotropin-releasing factor receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000583 COS-M6 Chlorocebus aethiops (Green monkey)  1
1
Ki = 0.42 nM
   TI
   LI
   LO
   TS
Protein ID: PT02596, Corticotropin-releasing factor receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000583 COS-M6 Chlorocebus aethiops (Green monkey)  1
1
Ki = 0.62 nM
   TI
   LI
   LO
   TS