General Information of the Compound
Compound ID
CP0467250
Compound Name
5-[(2-chlorobenzoyl)amino]-N-[2-[1-(4-pyridinyl)-4-piperidinyl]ethyl]-1H-pyrazole-3-carboxamide
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Structure
Formula
C23H25ClN6O2
Molecular Weight
452.946
Canonical SMILES
Clc1ccccc1C(=O)Nc1cc(n[nH]1)C(=O)NCCC1CCN(CC1)c1ccncc1
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InChI
InChI=1S/C23H25ClN6O2/c24-19-4-2-1-3-18(19)22(31)27-21-15-20(28-29-21)23(32)26-12-5-16-8-13-30(14-9-16)17-6-10-25-11-7-17/h1-4,6-7,10-11,15-16H,5,8-9,12-14H2,(H,26,32)(H2,27,28,29,31)
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InChIKey
PVZCAMQXLYHGIF-UHFFFAOYSA-N
Physicochemical Property
logP
3.7469
Rotatable Bonds
7
Heavy Atom Count
32
Polar Areas
103.01
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 23630810
SID: 46492278
ChEMBL ID
CHEMBL390692
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01032, B1 bradykinin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000411 IMR-90 Homo sapiens (Human)  1
1
IC50 = 200 nM
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