General Information of the Compound
Compound ID
CP0465492
Compound Name
4-[5,7,7,10,10-pentamethyl-2-(naphthalene-1-sulfonylamino)-7,8,9,10-tetrahydro-5H-5,13-diaza-benzo[4,5]cyclohepta[1,2-b]naphthalen-12-yl]-benzoic acid
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Structure
Formula
C39H37N3O4S
Molecular Weight
643.809
Canonical SMILES
CN1c2ccc(NS(=O)(=O)c3cccc4ccccc34)cc2N=C(c2ccc(cc2)C(O)=O)c2cc3c(cc12)C(C)(C)CCC3(C)C
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InChI
InChI=1S/C39H37N3O4S/c1-38(2)19-20-39(3,4)31-23-34-29(22-30(31)38)36(25-13-15-26(16-14-25)37(43)44)40-32-21-27(17-18-33(32)42(34)5)41-47(45,46)35-12-8-10-24-9-6-7-11-28(24)35/h6-18,21-23,41H,19-20H2,1-5H3,(H,43,44)
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InChIKey
FIHASMHGRHRIGK-UHFFFAOYSA-N
Physicochemical Property
logP
8.9382
Rotatable Bonds
5
Heavy Atom Count
47
Polar Areas
99.07
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
47

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44433476
ChEMBL ID
CHEMBL391572
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01930, Retinoic acid receptor RXR-alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 850 nM
   TI
   LI
   LO
   TS
2
IC50 = 3400 nM
   TI
   LI
   LO
   TS