General Information of the Compound
Compound ID
CP0462687
Compound Name
1-(5-bromo-2-methoxy-4-phenylmethoxybenzoyl)-3,4-bis(3,4-dimethoxyphenyl)pyrrole-2,5-dione
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Structure
Formula
C35H30BrNO9
Molecular Weight
688.527
Canonical SMILES
COc1ccc(cc1OC)C1=C(C(=O)N(C(=O)c2cc(Br)c(OCc3ccccc3)cc2OC)C1=O)c1ccc(OC)c(OC)c1
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InChI
InChI=1S/C35H30BrNO9/c1-41-25-13-11-21(15-29(25)44-4)31-32(22-12-14-26(42-2)30(16-22)45-5)35(40)37(34(31)39)33(38)23-17-24(36)28(18-27(23)43-3)46-19-20-9-7-6-8-10-20/h6-18H,19H2,1-5H3
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InChIKey
UQIPIIANKSPVQD-UHFFFAOYSA-N
Physicochemical Property
logP
6.1911
Rotatable Bonds
11
Heavy Atom Count
46
Polar Areas
109.83
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
9
Complexity
46

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 122185091
ChEMBL ID
CHEMBL3601683
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01546, ATP-dependent translocase ABCB1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000350 MDA435/LCC6MDR1 Homo sapiens (Human)  1
1
IC50 = 24.6 nM
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