General Information of the Compound
Compound ID
CP0462209
Compound Name
3-[[1-ethyl-5-[3-[4-(3-ethyl-3-hydroxypentoxy)-3-methylphenyl]pentan-3-yl]pyrrole-2-carbonyl]amino]-4-methoxy-4-oxobutanoic acid
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Structure
Formula
C31H46N2O7
Molecular Weight
558.716
Canonical SMILES
CCn1c(ccc1C(CC)(CC)c1ccc(OCCC(O)(CC)CC)c(C)c1)C(=O)NC(CC(O)=O)C(=O)OC
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InChI
InChI=1S/C31H46N2O7/c1-8-30(38,9-2)17-18-40-25-15-13-22(19-21(25)6)31(10-3,11-4)26-16-14-24(33(26)12-5)28(36)32-23(20-27(34)35)29(37)39-7/h13-16,19,23,38H,8-12,17-18,20H2,1-7H3,(H,32,36)(H,34,35)
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InChIKey
OSFRGHHYOARBJF-UHFFFAOYSA-N
Physicochemical Property
logP
4.98862
Rotatable Bonds
16
Heavy Atom Count
40
Polar Areas
127.09
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137651328
ChEMBL ID
CHEMBL4079382
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02378, Vitamin D3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000018 HL-60 Homo sapiens (Human)  1
1
EC50 = 26 nM
   TI
   LI
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   TS
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000083 MCF-7 Homo sapiens (Human)  1
1
IC50 = 10210 nM
   TI
   LI
   LO
   TS
CL000159 L-02 Homo sapiens (Human)  1
1
IC50 = 7590 nM
   TI
   LI
   LO
   TS