General Information of the Compound
Compound ID
CP0460455
Compound Name
1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[6-[3-(4-methylsulfonylpiperazin-1-yl)propoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea
    Show/Hide
Structure
Formula
C31H37N7O5S2
Molecular Weight
651.815
Canonical SMILES
CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCCN4CCN(CC4)S(C)(=O)=O)ccc32)no1
    Show/Hide
InChI
InChI=1S/C31H37N7O5S2/c1-31(2,3)27-19-28(35-43-27)34-29(39)32-22-8-6-21(7-9-22)24-20-38-25-11-10-23(18-26(25)44-30(38)33-24)42-17-5-12-36-13-15-37(16-14-36)45(4,40)41/h6-11,18-20H,5,12-17H2,1-4H3,(H2,32,34,35,39)
    Show/Hide
InChIKey
OHUFQEWUUDFDSC-UHFFFAOYSA-N
Physicochemical Property
logP
5.4916
Rotatable Bonds
9
Heavy Atom Count
45
Polar Areas
134.31
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
10
Complexity
45

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 44598530
SID: 87331026
ChEMBL ID
CHEMBL585002
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01204, Receptor-type tyrosine-protein kinase FLT3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Kd = 9.7 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000091 MV4-11 Homo sapiens (Human)  1
1
IC50 = 1.1 nM
   TI
   LI
   LO
   TS