General Information of the Compound
Compound ID
CP0459016
Compound Name
2-(4-fluoro-3-methoxyphenyl)-11-phenyl-4,9-dioxa-3,10-diazatetradeca-2,10-dien-14-oic acid
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Structure
Formula
C23H27FN2O5
Molecular Weight
430.476
Canonical SMILES
COc1cc(ccc1F)C(\C)=N\OCCCCO\N=C(\CCC(O)=O)c1ccccc1
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InChI
InChI=1S/C23H27FN2O5/c1-17(19-10-11-20(24)22(16-19)29-2)25-30-14-6-7-15-31-26-21(12-13-23(27)28)18-8-4-3-5-9-18/h3-5,8-11,16H,6-7,12-15H2,1-2H3,(H,27,28)/b25-17+,26-21-
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InChIKey
AKHWDHRUVKJZKN-TUQRYJEVSA-N
Physicochemical Property
logP
4.6408
Rotatable Bonds
13
Heavy Atom Count
31
Polar Areas
89.71
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46229903
ChEMBL ID
CHEMBL589747
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00910, Peroxisome proliferator-activated receptor alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 400 nM
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Protein ID: PT00915, Peroxisome proliferator-activated receptor gamma
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 700 nM
   TI
   LI
   LO
   TS