General Information of the Compound
Compound ID
CP0455750
Compound Name
[4-[[3-[1-(2-methylpropanoyl)piperidin-4-yl]-2,5-dioxoimidazolidin-4-yl]methyl]phenyl] isoquinoline-5-sulfonate
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Structure
Formula
C28H30N4O6S
Molecular Weight
550.637
Canonical SMILES
CC(C)C(=O)N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O
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InChI
InChI=1S/C28H30N4O6S/c1-18(2)27(34)31-14-11-21(12-15-31)32-24(26(33)30-28(32)35)16-19-6-8-22(9-7-19)38-39(36,37)25-5-3-4-20-17-29-13-10-23(20)25/h3-10,13,17-18,21,24H,11-12,14-16H2,1-2H3,(H,30,33,35)
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InChIKey
GBNYNPFPSQWZSM-UHFFFAOYSA-N
Physicochemical Property
logP
3.1124
Rotatable Bonds
7
Heavy Atom Count
39
Polar Areas
125.98
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71465399
SID: 163427654
ChEMBL ID
CHEMBL3415311
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01449, P2X purinoceptor 7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 7220 nM
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