General Information of the Compound
Compound ID
CP0454843
Compound Name
N-[5-[3-[[5-[(3R)-4-(5-acetylpyridin-2-yl)-3-methylpiperazine-1-carbonyl]-3-methylthieno[2,3-c]pyrazol-1-yl]methyl]phenoxy]pentyl]-3-(2,2-difluoro-10,12-dimethyl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaen-4-yl)propanamide
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Structure
Formula
C45H51BF2N8O4S
Molecular Weight
848.83
Canonical SMILES
C[C@@H]1CN(CCN1c1ccc(cn1)C(C)=O)C(=O)c1cc2c(C)nn(Cc3cccc(OCCCCCNC(=O)CCC4=[N+]5C(C=C4)=Cc4c(C)cc(C)n4[B-]5(F)F)c3)c2s1
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InChI
InChI=1S/C45H51BF2N8O4S/c1-29-22-30(2)55-40(29)24-37-14-13-36(56(37)46(55,47)48)15-17-43(58)49-18-7-6-8-21-60-38-11-9-10-34(23-38)28-54-45-39(32(4)51-54)25-41(61-45)44(59)52-19-20-53(31(3)27-52)42-16-12-35(26-50-42)33(5)57/h9-14,16,22-26,31H,6-8,15,17-21,27-28H2,1-5H3,(H,49,58)/t31-/m1/s1
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InChIKey
WAUJZTNSAILDDF-WJOKGBTCSA-N
Physicochemical Property
logP
7.56756
Rotatable Bonds
15
Heavy Atom Count
61
Polar Areas
117.6
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
10
Complexity
61

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137631419
ChEMBL ID
CHEMBL4067818
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02513, Steroid hormone receptor ERR1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 80 nM
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