General Information of the Compound
Compound ID
CP0454177
Compound Name
(R)-3-(4-fluorophenyl)-N-((R)-7-((isobutylamino)methyl)chroman-4-yl)-3-(3-(trifluoromethyl)phenylsulfonamido)-propanamide
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Structure
Formula
C30H33F4N3O4S
Molecular Weight
607.67
Canonical SMILES
CC(C)CNCc1ccc2[C@@H](CCOc2c1)NC(=O)C[C@@H](NS(=O)(=O)c1cccc(c1)C(F)(F)F)c1ccc(F)cc1
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InChI
InChI=1S/C30H33F4N3O4S/c1-19(2)17-35-18-20-6-11-25-26(12-13-41-28(25)14-20)36-29(38)16-27(21-7-9-23(31)10-8-21)37-42(39,40)24-5-3-4-22(15-24)30(32,33)34/h3-11,14-15,19,26-27,35,37H,12-13,16-18H2,1-2H3,(H,36,38)/t26-,27-/m1/s1
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InChIKey
UAXUURASZQTGIL-KAYWLYCHSA-N
Physicochemical Property
logP
5.6398
Rotatable Bonds
11
Heavy Atom Count
42
Polar Areas
96.53
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 16221057
SID: 24903526
ChEMBL ID
CHEMBL389478
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01032, B1 bradykinin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000389 CHO-DXB11 Cricetulus griseus (Chinese hamster)  2
1
IC50 = 14.8 nM
   TI
   LI
   LO
   TS
2
Ki = 5.9 nM
   TI
   LI
   LO
   TS